CloneCNA is a tool to detect copy number variation (CNV) in heterogeneous tumor samples in whole-genome exome sequencing data. The CloneCNA algorithm identifies clonal and subclonal CNVs by computing the log-ratio of the read counts of paired healthy samples and tumor B allele frequencies in germline at independent SNP locations.
Genetics; molecular genetics; human genetics; genetic variation; Oncology
Yu Z, Li A, Wang M "CloneCNA: detecting subclonal somatic copy number alterations in heterogeneous tumor samples from whole-exome sequencing data." BMC Bioinformatics. 2016 Aug 19;17:310. https://doi.org/10.1186/s12859-016-1174-7
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