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DBS (Deviation Binary Segmentation) is a tool for segmenting copy number variable (CNV) genomic locations. The inspiration for the DBS algorithm originates from the segmentation method based on the circular binary segmentation method. It uses a point-by-point model calculation coupled with a binary search algorithm with heuristics derived from the Central Limit Theorem. DBS can measure the change-point amplitude of mean values of two neighboring segments at a breakpoint.


Genetics; DNA structural variation


  • Operation: Structural variation detection
  • Software interface: Graphical user interface
  • Language: Java
  • Operating system: Microsoft Windows, Mac OS X, Linux
  • License: Apache License 2.0
  • Cost: Free
  • Version name: 1.2
  • Credit: The Natural Science Foundation of China, Health and Family Planning Commission of Wuhan City of China.
  • Contact: Guoqiang Yu yug _at_
  • Collection: -


Ruan J, Liu Z, Sun M, Wang Y, Yue J, Yu G "DBS: a fast and informative segmentation algorithm for DNA copy number analysis." BMC Bioinformatics. 2019 Jan 3;20(1):1.
PMID: 30606105
PMCID: PMC6318921

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