MixHMM is a tool for inferring copy number variation (CNV) and allelic imbalance from single nucleotide polymorphism (SNP) array data. The MixHMM algorithm uses a unique hidden Markov model (HMM) for chromosomal structural aberrations as hidden states and an innovative sample mixing design to detect tumor CNV in heterogeneous samples.
Genetics; Oncology; Genetic variation
Liu Z, Li A, Schulz V, Chen M, Tuck D "MixHMM: inferring copy number variation and allelic imbalance using SNP arrays and tumor samples mixed with stromal cells." PLoS One. 2010 Jun 1;5(6):e10909. https://doi.org/10.1371/journal.pone.0010909
PMID: 20532221
PMCID: PMC2879364
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