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NanoStringNormCNV is a tool for pre-processing and copy number variation (CNV) calling from NanoString data. The algorithm obtains a cohort mean by computing sample averages and normalized to obtain sample-specific data. It detects CNVs from count ratios of probes or genes and uses kernel density to compute thresholds, that are either set or dynamically computed range for pooled reference.


DNA structural variation; Sequence analysis; Nucleic acid sites, features and motifs


  • Operation: Read pre-processing; Copy number estimation
  • Input: RCC
  • Output: -
  • Software interface: Command-line user interface; Library
  • Language: R
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: 1.1.1
  • Credit: The Ontario Institute for Cancer Research, Terry Fox Research Institute and CIHR New Investigator Awards and Prostate Cancer Canada funded by Movember Foundation [#RS2014-01].
  • Contact: paul.boutros _at_
  • Collection: -


Sendorek DH, Lalonde E, Yao CQ, Sabelnykova VY, Bristow RG, Boutros PC "NanoStringNormCNV: pre-processing of NanoString CNV data." Bioinformatics. 2018 Mar 15;34(6):1034-1036.
PMID: 29112706
PMCID: PMC5860631

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