PICNIC is a software tool to predict copy number variation (CNV) in microarray cancer data. The PICNIC algorithm uses a unique preprocessing transformation and a hidden Markov Model (HMM) which is specific to cancer data. It classifies genotypes, specifies regions of loss of heterozygosity (LOH), and produces allelic copy number segmentation.
Genetics; Oncology; Genetic variation
Greenman CD, Bignell G, Butler A, Edkins S, Hinton J, Beare D, Swamy S, Santarius T, Chen L, Widaa S, Futreal PA, Stratton MR "PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data." Biostatistics. 2010 Jan;11(1):164-75. 2009 Oct 15. https://doi.org/10.1093/biostatistics/kxp045
PMID: 19837654
PMCID: PMC2800165
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