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PyLOH
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PyLOH

PyLOH is a tool for detecting copy number variation (CNV) and loss of heterozygosity in cancer genomes. The algorithm uses a unified probabilistic framework.



PyLOH

PyLOH is a tool for detecting copy number variation (CNV) and loss of heterozygosity in cancer genomes. The algorithm uses a unified probabilistic framework.

Topic

Oncology; DNA; DNA polymorphism

Details

  • Operation: Variant calling
  • Input: FASTA
  • Output: -
  • Software interface: Command-line user interface
  • Language: R;Python
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
    • Cost: Free
  • Version name: 1.1
  • Credit: The National Institutes of Health (grant R01HG006870).
  • Contact: yil8 _at_ uci.edu
  • Collection: -

Publications

Li Y, Xie X "Deconvolving tumor purity and ploidy by integrating copy number alterations and loss of heterozygosity." Bioinformatics. 2014 Aug 1;30(15):2121-9. https://doi.org/10.1093/bioinformatics/btu174
PMID: 24695406
PMCID: PMC4103592


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