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TITAN is a tool for estimation of copy number variation (CNV) and loss of heterozygosity (LOH) in whole-genome sequencing data consisting of clonal cell populations. The TITAN algorithm uses hidden Marlov model (HMM).
Alternative name: TitanCNA


Genetics; Whole genome sequencing; DNA structural variation; Oncology


  • Operation: Polymorphism detection; Sequence analysis; Structural variation detection
  • Software interface: Command-line user interface; Library
  • Language: R
  • Operating system: Microsoft Windows, Mac OS X, Linux
  • License: GNU GPL v3
  • Cost: Free
  • Version name: 1.22.0
  • Maturity: Stable
  • Credit: British Columbia Cancer Foundation, the Canadian Institutes for Health Research (CIHR), Genome Canada/Genome British Columbia, Canadian Cancer Society Research Institute, the Terry Fox Research Institute, Michael Smith Foundation for Health Research, Natural Sciences and Engineering Research Council of Canada.
  • Contact: gavinha _at_ | gha _at_ | Sohrab P. Shah sshah _at_
  • Collection: BioConductor


Ha G, Roth A, Khattra J, Ho J, Yap D, Prentice LM, Melnyk N, McPherson A, Bashashati A, Laks E, Biele J, Ding J, Le A, Rosner J, Shumansky K, Marra MA, Gilks CB, Huntsman DG, McAlpine JN, Aparicio S, Shah SP "TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data." Genome Res. 2014 Nov;24(11):1881-93. 24.
PMID: 25060187
PMCID: PMC4216928

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J1, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M "Orchestrating high-throughput genomic analysis with Bioconductor." Nat Methods. 2015 Feb;12(2):115-21.
PMID: 25633503
PMCID: PMC4509590

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. "Bioconductor: open software development for computational biology and bioinformatics." Genome Biol. 2004;5(10):R80. Epub 2004 Sep 15.
PMID: 15461798
PMCID: PMC545600

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