For better experience, turn on JavaScript!



TrioCNV is a tool designed for the detection of copy number variation (CNV), jointly occurring in parents and offsprings. The algorithm uses negative binomials regression, evaluates GC content and mappability biases, constrained by Mendelian inheritance, and combines these models using Hidden Markov Model (HMM).


Genetics; Whole genome sequencing; Genetics; Genetic variation


  • Operation: variation detection
  • Software interface: Command-line user interface
  • Language: R;Java
  • Operating system: Linux
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Credit: Natural Science Foundation of China [No: 61173085] and the National High-Tech Research and Development Program (863) of China [Nos: 2012AA020404, 2012AA02A602, 2012AA02A604 and 2014AA021505] and the National Institute of Health grant 1R01HG006857-01A1 (to B.L.).
  • Contact: yzhuangliu _at_
  • Collection: -


Liu Y, Liu J, Lu J, Peng J, Juan L, Zhu X, Li B, Wang Y "Joint detection of copy number variations in parent-offspring trios." Bioinformatics. 2016 Apr 15;32(8):1130-7.
PMID: 26644415
PMCID: PMC4907378

Download and documentation

If you find errors, please report here.