Genome-Wide Structural Equation Modeling. A method to test the association of a SNP with multiple phenotypes or a latent construct on a genome-wide basis using a diagonally weighted least squares (DWLS) estimator for four common SEMs; a one-factor model, a one-factor residuals model, a two-factor model, and a latent growth model.
DNA polymorphism, Genomics, Genetic variation, GWAS study
Verhulst B, Maes HH, Neale MC "GW-SEM: A Statistical Package to Conduct Genome-Wide Structural Equation Modeling." Behav. Genet. 2017; 47(3):345-359 https://doi.org/10.1007/s10519-017-9842-6
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