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Simulates common DNA variants and generates sequencing reads for mixture genomes. Features; 1. Simulates both germline and somatic variants, 2. Generates reads corresponding to heterogeneous genomes and produces tumor-normal matched samples, 3. Simulates correlations among SNPs, among CNVs/CNAs based on HMM models, 4. Simulates broad and focal CNV/CNA events.


DNA, Genomics, DNA mutation, Sequencing



Yuan X, Zhang J, Yang L "IntSIM: An Integrated Simulator of Next-Generation Sequencing Data." IEEE Trans Biomed Eng 2017; 64(2):441-451
PMID: 27164567

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