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PANTHER Database and Tools

PANTHER Database and Tools

Protein classification to ease high-throughput analyses. Classification is by family and subfamily, molecular function, biological process, and pathway. Updated single-nucleotide polymorphisms (SNP) scoring tool.


Sequence sites, features and motifs, Gene and protein families, Pathology, Molecular interactions, pathways and networks, Genetic variation


  • Operation: Over-representation analysis, Haplotype mapping, Protein modelling (mutation)
  • Software interface: Web user interface
  • Language: -
  • Operating system: Microsoft Windows, Mac OS X, Linux
  • License: Not stated
  • Cost: -
  • Version name: 14.0
  • Credit: Mi H, Huang X, Muruganujan A, Tang H, Mills, Kang, Thomas PD
  • Contact: -
  • Collection: -


Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D, Thomas PD "PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements." Nucleic Acids Res. 2017; 45(D1):D183-D189
PMID: 27899595
PMCID: PMC5210595

Mi H, Muruganujan A, Casagrande JT, Thomas PD "Large-scale gene function analysis with the PANTHER classification system." Nat Protoc. 2013 Aug;8(8):1551-66.
PMID: 23868073
PMCID: PMC6519453

Mi H, Muruganujan A, Huang X, Ebert D, Mills C, Guo X, Thomas PD "Protocol Update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)." Nat Protoc. 2019 Mar;14(3):703-721.
PMID: 30804569
PMCID: PMC6519457

Mi H, Lazareva-Ulitsky B, Loo R, Kejariwal A, Vandergriff J, Rabkin S, Guo N, Muruganujan A, Doremieux O, Campbell MJ, Kitano H, Thomas PD "The PANTHER database of protein families, subfamilies, functions and pathways." Nucleic Acids Res. 2005 Jan 1;33(Database issue):D284-8.
PMID: 15608197
PMCID: PMC540032

Mi H, Dong Q, Muruganujan A, Gaudet P, Lewis S, Thomas PD "PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium." Nucleic Acids Res. 2010 Jan;38(Database issue):D204-10.
PMID: 20015972
PMCID: PMC2808919

Mi H, Poudel S, Muruganujan A, Casagrande JT, Thomas PD "PANTHER version 10: expanded protein families and functions, and analysis tools." Nucleic Acids Res. 2016 Jan 4;44(D1):D336-42.
PMID: 26578592
PMCID: PMC4702852

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