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A web-based suite of tools to predict and analyze protein structure, function and mutations. It has advanced remote homology detection methods to build 3D models, predict ligand binding sites and analyze the effect of amino acid variants, e.g., non-synonymous SNPs.


Sequence analysis, Molecular modelling


  • Operation: Protein modelling, Protein feature detection, Sequence profile alignment
  • Software interface: Web user interface
  • Language:
  • Operating system: Linux, Microsoft Windows, Mac OS X
  • License: Other
  • Cost: FREE for commercial users
  • Version name: -
  • Credit: Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ.
  • Contact:
  • Collection: -


Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ "The Phyre2 web portal for protein modeling, prediction and analysis." Nat Protoc 2015; 10(6):845-58
PMID: 25950237
PMCID: PMC5298202

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