A tool to detect impurity and somatic variation, single nucleotide polymorphism (SNP), in somatic tumor sequencing data. The Virmid algorithm uses maximum likelihood estimator (MLE) for the joint probabilities of control and disease genotypes and sample contamination level.
Genetics; DNA polymorphism
Kim S, Jeong K, Bhutani K, Lee J, Patel A, Scott E, Nam H, Lee H, Gleeson JG, Bafna V "Virmid: accurate detection of somatic mutations with sample impurity inference." Genome Biol. 2013 Aug 29;14(8):R90. https://doi.org/10.1186/gb-2013-14-8-r90
PMID: 23987214
PMCID: PMC4054681
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