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A tool to detect impurity and somatic variation, single nucleotide polymorphism (SNP), in somatic tumor sequencing data. The Virmid algorithm uses maximum likelihood estimator (MLE) for the joint probabilities of control and disease genotypes and sample contamination level.


Genetics; DNA polymorphism


  • Operation: SNP detection
  • Software interface: Command-line user interface
  • Language: Java
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: 1.2.0
  • Maturity: Stable
  • Credit: The National Science Foundation, National Institute of Child Health and Human Development, The National Institutes of Health (NIH)
  • Contact: Sangwoo Kim sak042 _at_ | Vineet Bafna vbafna _at_
  • Collection: -


Kim S, Jeong K, Bhutani K, Lee J, Patel A, Scott E, Nam H, Lee H, Gleeson JG, Bafna V "Virmid: accurate detection of somatic mutations with sample impurity inference." Genome Biol. 2013 Aug 29;14(8):R90.
PMID: 23987214
PMCID: PMC4054681

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