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A software package to single-marker and gene-based analyses of X chromosome. It can perform various statistical tests, such as the standard test between a single nucleotide polymorphism (SNP) and disease risk, a test for a differential effect of a SNP on disease between males and females, motivated by X-inactivation, a test for higher variance of a trait in heterozygous females as compared with homozygous females, and for all tests, a version that allows for combining evidence from all SNPs across a gene.


Biology, Gnetetics, Molecular genetics, Genetic variation, DNA polymorphism


  • Operation: Statistical calculation, Statistical modelling
  • Software interface: Command-line interface
  • Language: C++
  • Operating system: Linux, Mac OS X, Microsoft Windows
  • License: GNU GPL v2
  • Cost: -
  • Version name: 3.0
  • Credit: Gao F, Chang D, Biddanda A, Ma L, Guo Y, Zhou Z, Keinan A.
  • Contact:
  • Collection: -


Gao F, Chang D, Biddanda A, Ma L, Guo Y, Zhou Z, Keinan A "XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome." J. Hered. 2015; 106(5):666-71
PMID: 26268243
PMCID: PMC4567842

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