FarmCPU (Fixed and random model Circulating Probability Unification) is a tool for genome-wide association analyses (GWAS). The algorithm uses the general linear model framework. Following single-marker regression, FarmCPU assigns the data into bins and classifies a set of optimal markers as covariates in the subsequent iteration.
Liu X, Huang M, Fan B, Buckler ES, Zhang Z "Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies" PLoS Genet. 2016 Feb 1;12(2):e1005767 https://doi.org/10.1371/journal.pgen.1005767
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