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LDSC is a tool to estimate heritability and genetic correlations in genome-wide association study (GWAS) dataset summary statistics. The LDSC algorithm uses linkage disequilibrium (LD) score regression among test statistics and LD to discriminate inflation from true polygenic signals and biases.


Mapping; Genetics


  • Operation: Statistical calculation
  • Software interface: Command-line user interface
  • Language: Python
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: GPL-3.0
  • Cost: Free
  • Version name: 1.0.1
  • Maturity: Stable
  • Credit: The National Institutes of Health (NIH), the Fannie and John Hertz Foundation (HF).
  • Contact: bneale _at_
  • Collection: -


Bulik-Sullivan BK, Loh PR, Finucane HK, Ripke S, Yang J, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N, Daly MJ, Price AL, Neale BM "LD Score regression distinguishes confounding from polygenicity in genome-wide association studies." Nat. Genet. 2015; 47(3):291-5
PMID: 25642630
PMCID: PMC4495769

Finucane HK, Bulik-Sullivan B, Gusev A, Trynka G, Reshef Y, Loh PR, Anttila V, Xu H, Zang C, Farh K, Ripke S, Day FR; ReproGen Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; RACI Consortium, Purcell S, Stahl E, Lindstrom S, Perry JR, Okada Y, Raychaudhuri S, Daly MJ, Patterson N, Neale BM, Price AL. "Partitioning heritability by functional annotation using genome-wide association summary statistics" Nat Genet. 2015 Nov;47(11):1228-35.
PMID: 26414678
PMCID: PMC4626285

Bulik-Sullivan B, Finucane HK, Anttila V, Gusev A, Day FR, Loh PR; ReproGen Consortium; Psychiatric Genomics Consortium; Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Duncan L, Perry JR, Patterson N, Robinson EB, Daly MJ, Price AL, Neale BM "An atlas of genetic correlations across human diseases and traits." Nat Genet. 2015 Nov;47(11):1236-41.
PMID: 26414676
PMCID: PMC4797329

Gazal S, Finucane HK, Furlotte NA, Loh PR, Palamara PF, Liu X, Schoech A, Bulik-Sullivan B, Neale BM, Gusev A, Price AL "Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection" Nat Genet. 2017 Oct;49(10):1421-1427
PMID: 28892061
PMCID: PMC6133304

Zheng J, Erzurumluoglu AM, Elsworth BL, Kemp JP, Howe L, Haycock PC, Hemani G, Tansey K, Laurin C; Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, Pourcain BS, Warrington NM, Finucane HK, Price AL, Bulik-Sullivan BK, Anttila V, Paternoster L, Gaunt TR, Evans DM, Neale BM "LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis" Bioinformatics. 2017 Jan 15;33(2):272-279.
PMID: 27663502
PMCID: PMC5542030

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