PARIS (Pathway Analysis by Randomization Incorporating Structure) is a tool for the analysis of pathways to aggregate signals in genome-wide association studies (GWAS) results. The PARIS algorithm clusters SNPs into LD, LE groups, creates groups according to pathways and tests the significance by permutation testing. The download requires registering.
Genetics; Genomics; Molecular interactions, pathways and networks
Yaspan BL, Bush WS, Torstenson ES, Ma D, Pericak-Vance MA, Ritchie MD, Sutcliffe JS, Haines JL "Genetic analysis of biological pathway data through genomic randomization." Hum. Genet. 2011; 129(5):563-71 https://doi.org/10.1007/s00439-011-0956-2
PMID: 21279722
PMCID: PMC3107984
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