PEPIS (Pipeline for estimating EPIStatic genetic effects) is a web-based tool for the estimation of polygenic Epistatic QTL mapping for genome-wide association studies (GWAS). The PEPIS algorithm uses a new linear mixed model and includes kinship matrix calculation, polygenic component analyses, and genome scanning for main and epistatic effects.
Mapping; GWAS study; Genetics
Zhang W, Dai X, Wang Q, Xu S, Zhao PX "PEPIS: A Pipeline for Estimating Epistatic Effects in Quantitative Trait Locus Mapping and Genome-Wide Association Studies." PLoS Comput. Biol. 2016; 12(5):e1004925 https://doi.org/10.1371/journal.pcbi.1004925
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