PheWAS (Phenome-wide association studies) is a tool for genome-wide association studies (GWAS). The method has the potential to identify therapeutic and adverse drug outcomes in electronic health record data.
Phenomics; Genotype and phenotype; GWAS study
Choi L, Carroll RJ, Beck C, Mosley JD, Roden DM, Denny JC, Van Driest SL "Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects." Bioinformatics 2018; 34(17):2988-2996 https://doi.org/10.1093/bioinformatics/bty306
PMID: 29912272
PMCID: PMC6129383
Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, Wang D, Masys DR, Roden DM, Crawford DC "PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations." Bioinformatics 2010; 26(9):1205-10 https://doi.org/10.1093/bioinformatics/btq126
PMID: 20335276
PMCID: PMC2859132
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