SIMreg is a tool for maker-set association analysis at gene, pathway, and exon levels to evaluate the etiological effects of genes in genome-wide association study (GWAS) or sequence data.
Genetics; Molecular interactions, pathways and networks; Gene transcripts; GWAS study
Tzeng JY, Zhang D, Pongpanich M, Smith C, McCarthy MI, Sale MM, Worrall BB, Hsu FC, Thomas DC, Sullivan PF "Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression." Am. J. Hum. Genet. 2011; 89(2):277-88 https://doi.org/10.1016/j.ajhg.2011.07.007
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