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SIMreg is a tool for maker-set association analysis at gene, pathway, and exon levels to evaluate the etiological effects of genes in genome-wide association study (GWAS) or sequence data.


Genetics; Molecular interactions, pathways and networks; Gene transcripts; GWAS study


  • Operation: Sequence analysis
  • Software interface: Command-line user interface
  • Language: R, C
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: GNU General Public License v>=2
  • Cost: Free
  • Version name: 2.14
  • Credit: The National Institutes of Health (NIH), the Wake Forest University General Clinical Research Center.
  • Contact: tzeng _at_ | jytzeng _at_ | Chris Smith chris _at_
  • Collection: -


Tzeng JY, Zhang D, Pongpanich M, Smith C, McCarthy MI, Sale MM, Worrall BB, Hsu FC, Thomas DC, Sullivan PF "Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression." Am. J. Hum. Genet. 2011; 89(2):277-88
PMID: 21835306
PMCID: PMC3155192

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