lme4 is a tool for fitting linear and generalized linear mixed-effects models. The lme4 algorithm presents models and components with S4 classes.
Experimental design and studies; GWAS study
Bates, Douglas, Martin Mächler, Ben Bolker, Steve Walker "Fitting Linear Mixed-Effects Models Using lme4" Journal of Statistical Software [Online], 67.1 (2015): 1 - 48. Web. 3 Feb. 2020 https://doi.org/10.18637/jss.v067.i01
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