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wtest is a tool for association testing of principal effects, pairwise and high order interactions in genome-wide association study (GWAS) data. The wtest also has functions for genome-wide and epigenome-wide testing of the cis-regulation of SNP and CpG sites.


Genetics; GWAS study; Protein interactions; DNA


  • Operation: Statistical calculation
  • Software interface: Command-line user interface
  • Language: R, C++
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: GNU GPL v2
  • Cost: Free
  • Version name: 3.2
  • Maturity: Stable
  • Credit: NSFC
  • Contact: Rui Sun rsunzju at | maggiew _at_
  • Collection: -


Sun R, Xia X, Chong KC, Zee BC, Wu WKK, Wang MH "wtest: an integrated R package for genetic epistasis testing." BMC Med Genomics 12(Suppl 9): 180.
PMID: 31874630
PMCID: PMC6929460

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