ALRA (Adaptively-thresholded Low Rank Approximation) is a tool for genotype imputation. The ALRA algorithm uses a low-rank approximation method to capture expressed gene dropouts. ALRA is also integrated into Seurat v3.0.
Population genetics; Transcriptomics; Gene expression
George C. Linderman, Jun Zhao, Yuval Kluger "Zero-preserving imputation of scRNA-seq data using low-rank approximation" bioRxiv 397588 https://doi.org/10.1101/397588
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