A tool for genotype imputation and phasing. The AlphaImpute algorithm requires pedigree data and couples the long-range phasing with a segregation analysis and haplotype library imputation (SAHLI). The tool is available via email from the Authors.
Population genetics
Antolín R, Nettelblad C, Gorjanc G, Money D, Hickey JM "A hybrid method for the imputation of genomic data in livestock populations." Genet Sel Evol. 2017 Mar 3;49(1):30. https://doi.org/10.1186/s12711-017-0300-y
PMID: 28253858
PMCID: PMC5439152
Hickey JM, Cleveland MA, Maltecca C, Gorjanc G, Gredler B, Kranis A "Genotype imputation to increase sample size in pedigreed populations." Methods Mol Biol. 2013;1019:395-410. https://doi.org/10.1007/978-1-62703-447-0_17
PMID: 23756901
Sun C, Wu XL, Weigel KA, Rosa GJ, Bauck S, Woodward BW, Schnabel RD, Taylor JF, Gianola D "An ensemble-based approach to imputation of moderate-density genotypes for genomic selection with application to Angus cattle." Genet Res (Camb). 2012 Jun;94(3):133-50. https://doi.org/10.1017/S001667231200033X
PMID: 22809677
Hickey JM, Kinghorn BP, Tier B, van der Werf JH, Cleveland MA "A phasing and imputation method for pedigreed populations that results in a single-stage genomic evaluation." Genet Sel Evol. 2012 Jun 19;44:9. https://doi.org/10.1186/1297-9686-44-9
PMID: 22462519
PMCID: PMC3378429
Hickey JM, Kranis A "Extending long-range phasing and haplotype library imputation methods to impute genotypes on sex chromosomes." Genet Sel Evol. 2013 Apr 25;45:10. https://doi.org/10.1186/1297-9686-45-10
PMID: 23617460
PMCID: PMC3642030
Bouwman AC, Hickey JM, Calus MP, Veerkamp RF "Imputation of non-genotyped individuals based on genotyped relatives: assessing the imputation accuracy of a real case scenario in dairy cattle." Genet Sel Evol. 2014 Feb 3;46:6 https://doi.org/10.1186/1297-9686-46-6
PMID: 24490796
PMCID: PMC3929150
Liu X, Hinney A, Scholz M, Scherag A, Tönjes A, Stumvoll M, Stadler PF, Hebebrand J, Böttcher Y "Indications for potential parent-of-origin effects within the FTO gene." PLoS One. 2015 Mar 20;10(3):e0119206. https://doi.org/10.1371/journal.pone.0119206
PMID: 25793382
PMCID: PMC4368796
Cleveland MA, Hickey JM "Practical implementation of cost-effective genomic selection in commercial pig breeding using imputation." J Anim Sci. 2013 Aug;91(8):3583-92. https://doi.org/10.2527/jas.2013-6270
PMID: 23736050
Ma P, Brøndum RF, Zhang Q, Lund MS, Su G "Comparison of different methods for imputing genome-wide marker genotypes in Swedish and Finnish Red Cattle." J Dairy Sci. 2013 Jul;96(7):4666-77. https://doi.org/10.3168/jds.2012-6316
PMID: 23684022
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