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A tool for genotype imputation. The FISH algorithm uses a hidden Markov model to characterize single reference haplotypes.


Protein folds and structural domains; Sequence sites, features and motifs; Gene and protein families; Proteins; Sequencing


  • Operation: Pairwise sequence alignment; Protein fold recognition; Structured RNA prediction and optimisation; Protein domain recognition; Protein structural motif recognition
  • Software interface: Web user interface
  • Language: Java
  • Operating system: Linux; Mac OS X: Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Credit: National Natural Science Foundation of China, National Institutes of Health, Franklin D. Dickson/Missouri Endowment and the Edward G. Schlieder Endowment
  • Contact: lzhang6 _at_ | zlbio12 _at_
  • Collection: -


Zhang L, Pei YF, Fu X, Lin Y, Wang YP, Deng HW "FISH: fast and accurate diploid genotype imputation via segmental hidden Markov model." Bioinformatics. 2014 Jul 1;30(13):1876-83. Epub 2014 Mar 10.
PMID: 24618466
PMCID: PMC4071209

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