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A tool to impute human leukocyte antigen (HLA) genotypes and matching. The GRIMM algorithm uses a graph-based method to store haplotype frequencies.


Population genetics


  • Operation: Imputation
  • Software interface: Command-line user interfacae
  • Language: Perl, Python
  • Operating system: Microsoft Windows, Mac OS X, Linux
  • License: GNU Lesser General Public License version 3
  • Cost: Free
  • Version name: -
  • Maturity: Stable
  • Credit: US Office of Naval Research
  • Contact: Yoram Louzoun louzouy _at_
  • Collection: -


Maiers M, Halagan M, Gragert L, Bashyal P, Brelsford J, Schneider J, Lutsker P, Louzoun Y "GRIMM: GRaph IMputation and Matching for HLA Genotypes." Bioinformatics. 2019 Jan 28. pii: 5303534.
PMID: 30689784

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