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HLA*IMP

HLA*IMP

A tool for genotype imputation of human leukocyte antigen (HLA) alleles. The HLA*IMP algorithm uses linked SPN data, prepares local data, performs probabilistic imputation through a remote server, and QC.

Topic

Population genetics

Details

  • Operation: Imputation
  • Software interface: Command-line user interface; Graphical user interface
  • Language: C++, Perl
  • Operating system: Microsoft Windows, Mac OS X, Linux
  • License: Other, GNU GPL (front-end)
  • Cost: Free for academic use
  • Version name: -
  • Maturity: Stable
  • Credit: Studienstiftung des deutschen Volkes, Leverhulme Trust, Medical Research Council, Wellcome Trust.
  • Contact: Alexander Dilthey dilthey _at_ stats.ox.ac.uk
  • Collection: -

Publications

Dilthey AT, Moutsianas L, Leslie S, McVean G "HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes." Bioinformatics. 2011 Apr 1;27(7):968-72. 2011 Feb 7. https://doi.org/10.1093/bioinformatics/btr061
PMID: 21300701
PMCID: PMC3065693

Leslie S, Donnelly P, McVean G "A statistical method for predicting classical HLA alleles from SNP data." Am J Hum Genet. 2008 Jan;82(1):48-56. https://doi.org/10.1016/j.ajhg.2007.09.001
PMID: 18179884
PMCID: PMC2253983

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