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Human Protein Variant Effect Map Imputation Toolkit

Human Protein Variant Effect Map Imputation Toolkit

A web-based pipeline tool for genotype imputation and visualization of missense variant effect maps. The algorithm imputes lacking data in empirically observed effect maps.

Topic

Population genetics

Details

  • Operation: Imputation; Visualisation
  • Software interface: Web user interface
  • Language: Python, Javascript
  • Operating system: Mac OS X, Linux
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Maturity: Stable
  • Credit: the National Human Genome Research Institute of the National Institutes of Health Center of Excellence in Genomic Science, the Canada Excellence Research Chairs Program; a Canadian Institutes of Health Foundation, the One Brave Idea Foundation.
  • Contact: Frederick P Roth fritz.roth _at_ utoronto.ca
  • Collection: -

Publications

Wu Y, Weile J, Cote AG, Sun S, Knapp J, Verby M, Roth FP "A web application and service for imputing and visualizing missense variant effect maps." Bioinformatics. 2019 Sep 1;35(17):3191-3193. https://doi.org/10.1093/bioinformatics/btz012
PMID: 30649215

Download and documentation


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