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Human Protein Variant Effect Map Imputation Toolkit

Human Protein Variant Effect Map Imputation Toolkit

A web-based pipeline tool for genotype imputation and visualization of missense variant effect maps. The algorithm imputes lacking data in empirically observed effect maps.


Population genetics


  • Operation: Imputation; Visualisation
  • Software interface: Web user interface
  • Language: Python, Javascript
  • Operating system: Mac OS X, Linux
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Maturity: Stable
  • Credit: the National Human Genome Research Institute of the National Institutes of Health Center of Excellence in Genomic Science, the Canada Excellence Research Chairs Program; a Canadian Institutes of Health Foundation, the One Brave Idea Foundation.
  • Contact: Frederick P Roth fritz.roth _at_
  • Collection: -


Wu Y, Weile J, Cote AG, Sun S, Knapp J, Verby M, Roth FP "A web application and service for imputing and visualizing missense variant effect maps." Bioinformatics. 2019 Sep 1;35(17):3191-3193.
PMID: 30649215

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