Minimac4 is a tool for genotype imputation, an improved version of Minimac2. The Minimac Algorithm is a computationally efficient implementation of MaCH algorithm, works on phased genotypes and can handle large reference panels up to hundreds of thousands of haplotypes. It first identifies repeated haplotype patterns and uses these to speed up the computational process. Main improvements from previous versions: 1. About six times faster for the reference panels than Minimac3. 2. Decreased memory usage. 3. It can use varying ploidy in the same VCF file for imputation of sex chromosomes.
Das S, Forer L, Schonherr S, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C "Next-generation genotype imputation service and methods." Nat Genet. 2016 Oct;48(10):1284-1287. https://doi.org/10.1038/ng.3656
Fuchsberger C, Abecasis GR, Hinds DA "minimac2: faster genotype imputation." Bioinformatics. 2015 Mar 1;31(5):782-4. 2014 Oct 22. https://doi.org/10.1093/bioinformatics/btu704
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