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PRIMAL (PedigRee IMputation ALgorithm) is a tool for genotype imputation for founder populations having pedigree data. The PRIMAL algorithm is based on an indexing procedure of Identity-By-Descent segments using clique graphs.


Population genetics


  • Operation: Phasing; Imputation
  • Software interface: Command-line user interface
  • Language: Python
  • Operating system: Microsoft Windows, Mac OS X, Linux
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Maturity: Stable
  • Credit: The National Institutes of Health (NIH
  • Contact: Dan L. Nicolae nicolae _at_
  • Collection: -


Livne OE, Han L, Alkorta-Aranburu G, Wentworth-Sheilds W, Abney M, Ober C, Nicolae DL "PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population." PLoS Comput Biol. 2015 Mar 3;11(3):e1004139. eCollection 2015 Mar.
PMID: 25735005
PMCID: PMC4348507

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