Is a tool for genotype imputation. The Simpute algorithm does not require reference panels and works by evaluating two neighboring SNP loci around a missing target. It combines the estimated haplotype probabilities with LD data to predict the missing SNP genotype.
Population genetics
Lin YJ, Chang CT, Tang CY, Hsieh WP "Simpute: an efficient solution for dense genotypic data." Biomed Res Int. 2013;2013:813912. https://doi.org/10.1155/2013/813912
PMID: 23509783
PMCID: PMC3581137
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