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A tool for genotype imputation and estimating missing haplotypes. The fastPHASE algorithm obtains a random sample from a population data and models the genealogy of chromosomes and summarizes the haplotype variation. fastPHASE estimates and corrects genotyping errors based on linkage disequilibrium (LD) patterns, associates haplotypes with binary phenotypes, and works on low-coverage sequencing data.


Population genetics



Scheet P, Stephens M "A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase." Am J Hum Genet. 2006 Apr;78(4):629-44.
PMID: 16532393
PMCID: PMC1424677

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