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Divide-and-Conquer Multiple Sequence Alignmen (DCA). This tool uses a divide and conquers method to construct multiple sequence alignments (MSA) heuristically. It can align amino acid, DNA, and RNA sequences. The web site also provides REST services.


Genomics; Sequencing; Sequence analysis



Brinkmann G, Dress AWM, Perrey SW, Stoye J "Two applications of the divide&conquer principle in the molecular sciences" Mathematical Programming October 1997, Volume 79, Issue 1–3, pp 71–97

Stoye J, Moulton V, Dress AW "DCA: an efficient implementation of the divide-and-conquer approach to simultaneous multiple sequence alignment." Comput Appl Biosci. 1997 Dec;13(6):625-6.
PMID: 9475994

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