A tool for multiple sequence alignment (MSA) using "form-and-polish strategy." The Authors claim OPAL to be more accurate than Muscle and similar to Muscle on protein sequence alignment and have similar accuracy as MAFFT and Muscle on DNA sequence alignments.
Wheeler TJ, Kececioglu JD "Multiple alignment by aligning alignments." Bioinformatics. 2007 Jul 1;23(13):i559-68. https://doi.org/10.1093/bioinformatics/btm226
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