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Protein Variability Server (PVS) web server uses several variability metrics to calculate a sequence variability within a multiple protein sequence alignment. The tool can map the sequence variability to supplied 3D structure, plot the variability, mask the variability in a sequence, predict T-cell epitopes, locate conserved sequences in 3D structures, and return conserved sequence fragments.


Protein sites, features and motifs; Proteins; Gene and protein families; Sequence composition, complexity and repeats; Sequence analysis


  • Operation: Epitope mapping; Sequence alignment analysis (conservation); Protein sequence analysis; Sequence alignment; Multiple sequence alignment
  • Input: Multiple sequence alignment in FASTA, Clustal, PDB, or GCG/PileUp format
  • Output: -
  • Software interface: Web user interface
  • Language: -
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Credit: -
  • Contact: parecheg _at_
  • Collection: -


Garcia-Boronat M, Diez-Rivero CM, Reinherz EL, Reche PA "PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery." Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W35-41
PMID: 18442995
PMCID: PMC2447719

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