Protein Variability Server (PVS) web server uses several variability metrics to calculate a sequence variability within a multiple protein sequence alignment. The tool can map the sequence variability to supplied 3D structure, plot the variability, mask the variability in a sequence, predict T-cell epitopes, locate conserved sequences in 3D structures, and return conserved sequence fragments.
Protein sites, features and motifs; Proteins; Gene and protein families; Sequence composition, complexity and repeats; Sequence analysis
Garcia-Boronat M, Diez-Rivero CM, Reinherz EL, Reche PA "PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery." Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W35-41 https://doi.org/10.1093/nar/gkn211
PMID: 18442995
PMCID: PMC2447719
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