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Probabilistic Consistency-based Multiple Alignment of Amino Acid Sequences. It uses probabilistic modeling and consistenct-based technigues in the alignment construction. The Authors claim this tool to have improved alignments compared to T-Coffee, Clustal W, and Dialign.


Sequence analysis


  • Operation: Sequence comparison; Multiple sequence alignment
  • Software interface: Command-line user interface; Web user interface
  • Language: -
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: 1.12
  • Credit: -
  • Contact: chuongdo _at_
  • Collection: -


Do CB, Mahabhashyam MS, Brudno M, Batzoglou S "ProbCons: Probabilistic consistency-based multiple sequence alignment" Genome Res. 2005 Feb;15(2):330-40.
PMID: 15687296
PMCID: PMC546535

Download and documentation

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