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Non-B_DB

Non-B_DB

Non-B DB is an online database that contains non-B DNA forming sequence motifs. The Non-B DB includes predictions for Z-DNA, quadruplex-forming motifs, mirror repeats, inverted repeats, and direct repeats with subsets of cruciforms, triplex, and slipped structures.
The database also contains disease-associated motifs, such as short tandem repeats and homo(purine•pyrimidine) tracts.
The query results link to the UCSC browser and GBrowse-based genomic viewers.

Topic

Structure prediction; DNA; DNA polymorphism; Genetic variation; Structure analysis

Details

  • Operation: Quadruplex formation site detection; Query and retrieval; Sequence feature detection; DNA structure prediction; Repeat sequence analysis
  • Software interface: Database
  • Language: -
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Credit: Center for Biomedical Informatics and Information Technology (CBIIT)-Cancer Biomedical Informatics Grid (caBIG) ISRCE yellow task #09-260 to NCI-Frederick and National Cancer Institute-National Institutes of Health contract HHSN261200800001E (to A.B.). Funding for open access charge: National Cancer Institute-National Institutes of Health contract HHSN261200800001E.
  • Contact: stephensr _at_ mail.nih.gov
  • Collection: -

Publications

Cer RZ, Bruce KH, Mudunuri US, Yi M, Volfovsky N, Luke BT, Bacolla A, Collins JR, Stephens RM "Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes." Nucleic Acids Res. 2011; 39(Database issue):D383-91 https://doi.org/10.1093/nar/gkq1170
PMID: 21097885
PMCID: PMC3013731


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