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CHOP

CHOP

CHOP is a tool to predict protein domain boundaries using Pfam, PDB, and SWISS-PROT databases. The CHOP algorithm includes a homology-based and neural network-based (CHOPnet) methods.

Topic

Proteins; Protein folds and structural domains; Protein sites, features and motifs; Gene and protein families; Sequence composition, complexity and repeats

Details

  • Operation: Protein modelling; Protein sequence cleavage; Protein fold recognition; Protein sequence analysis; Sequence comparison
  • Input: FASTA
  • Output: XML | ASCII table, a HTML table, and a CASP DP
  • Software interface: Command-line user interface
  • Language: Perl
  • Operating system: Linux
  • License: Other
  • Cost: Free for non-commercial use
  • Version name: -
  • Credit: The National Institutes of Health (NIH), the National Library of Medicine (NLM).
  • Contact: rost _at_ columbia.edu
  • Collection: -

Publications

Liu J, Rost B "CHOP: parsing proteins into structural domains." Nucleic Acids Res. 2004; 32(Web Server issue):W569-71 https://doi.org/10.1093/nar/gkh481
PMID: 15215452
PMCID: PMC441619


Liu J, Rost B "Sequence-based prediction of protein domains." Nucleic Acids Res, 2004 https://doi.org/10.1093/nar/gkh684
PMID: 15240828
PMCID: PMC484172


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