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ProteinProphet
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ProteinProphet

ProteinProphet is a tool to identify proteins by tandem mass spectrometry. The ProteinProphet algorithm uses the expectation-maximization algorithm and learns from a subsequent dataset by how much peptide probabilities should be adjusted.



ProteinProphet

ProteinProphet is a tool to identify proteins by tandem mass spectrometry. The ProteinProphet algorithm uses the expectation-maximization algorithm and learns from a subsequent dataset by how much peptide probabilities should be adjusted.

Topic

Proteomics; Proteomics experiment; Statistics and probability

Details

  • Operation: Statistical modelling; Protein identification; Validation of peptide-spectrum matches; Filtering; de Novo sequencing
  • Software interface: Command-line user interface; Graphical user interface
  • Language: Perl, C
  • Operating system: Mac OS X
  • License: Other
    • Cost: Free
  • Version name: 5.0
  • Credit: National Institutes of Health (NIH)
  • Contact: adkeller _at_ users.sourceforge.net
  • Collection: -

Publications

Nesvizhskii AI, Keller A, Kolker E, Aebersold R "A statistical model for identifying proteins by tandem mass spectrometry." Anal. Chem. 2003; 75(17):4646-58 https://doi.org/10.1021/ac0341261
PMID: 14632076


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