An R tool for identification of gene signatures and modules in RNA-seq data. The AUCell algorithm detects and ranks enriched gene sets by computing the receiver operator characteristics, i.e., the area under the curve (AUC).
RNA-seq; Gene expression; Transcriptomics
Davie K, Janssens J, Koldere D, De Waegeneer M, Pech U, Kreft Ł, Aibar S, Makhzami S, Christiaens V, Bravo González-Blas C, Poovathingal S, Hulselmans G, Spanier KI, Moerman T, Vanspauwen B, Geurs S, Voet T, Lammertyn J, Thienpont B, Liu S, Konstantinides N, Fiers M, Verstreken P, Aerts S. "A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain." Cell. 2018 Aug 9;174(4):982-998.e20. https://doi.org/10.1016/j.cell.2018.05.057
PMID: 29909982
PMCID: PMC6086935
Aibar S, Gonzalez-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, Rambow F, Marine JC, Geurts P, Aerts J, van den Oord J, Atak ZK, Wouters J, Aerts S "SCENIC: single-cell regulatory network inference and clustering." Nat Methods. 2017 Nov;14(11):1083-1086. https://doi.org/10.1038/nmeth.4463
PMID: 28991892
PMCID: PMC5937676
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