DESeq2 is a tool for differential gene expression analysis of RNA-seq data. DESeq2 is a new version of DESeq and can detect more differentially expressed genes (DEGs) than DESeq2. However, it also seems to allow more false positives. The DESeq2 algorithm uses the negative binomial distribution, the Wald, and the Likelihood Ratio Tests.
Gene expression; Transcriptomics
Love MI, Huber W, Anders S "Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2." Genome Biol. 2014;15(12):550. https://doi.org/10.1186/s13059-014-0550-8
PMID: 25516281
PMCID: PMC4302049
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