DIEM (Debris Identification using Expectation Maximization) is a tool to remove debris-contaminated droplets in single nucleus snRNA-seq data. The DIEM algorithm uses the expression profile of background RNA droplets and expectation maximization (EM) to assign candidate debris.
RNA-Seq; Gene expression
Alvarez Marcus, Rahmani Elior, Jew Brandon, Garske Kristina M., Miao Zong, Benhammou Jihane N., Ye Chun Jimmie, Pisegna Joseph R., Pietiläinen Kirsi H., Halperin Eran, Pajukanta Päivi "Enhancing droplet-based single-nucleus RNA-seq resolution using the semi-supervised machine learning classifier DIEM" bioRxiv https://doi.org/10.1101/786285
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