For better experience, turn on JavaScript!


DeFuse

DeFuse

DeFuse is a tool for the identification of gene fusions in RNA-seq data. The deFuse algorithm examines all conflicting paired-end sequence alignments to find fusion boundaries.

Topic

Gene structure; RNA-seq; Gene transcripts; Oncology

Details

  • Operation: Sequence motif discovery; Splicing model analysis; Gene expression comparison; RNA-Seq analysis
  • Software interface: Command-line user interface
  • Language: C++
  • Operating system: Linux; Mac OS X
  • License: Other
  • Cost: Free for non-commercial use
  • Version name: -
  • Credit: The British Columbia Cancer Foundation, the Vancouver General Hospital Foundation, Genome Canada, the Michael Smith Foundation for Health Research, the Canadian Breast Cancer Foundation, the Canadian Institutes of Health Research Bioinformatics Training Program.
  • Contact: Sohrab P. Shah sshah _at_ bccrc.ca
  • Collection: -

Publications

McPherson A, Hormozdiari F, Zayed A, Giuliany R, Ha G, Sun MG, Griffith M, Heravi Moussavi A, Senz J, Melnyk N, Pacheco M, Marra MA, Hirst M, Nielsen TO, Sahinalp SC, Huntsman D, Shah SP "deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data." PLoS Comput. Biol. 2011; 7(5):e1001138 https://doi.org/10.1371/journal.pcbi.1001138
PMID: 21625565
PMCID: PMC3098195


Download and documentation








If you find errors, please report here.