A tool to map DNA and RNA sequences to one or more genomes. The HISAT2 algorithm uses an extension of the Burrows-Wheeler transform (BWT) to generate graphs, a new graph FM index (GFM), and a Hierarchical Graph FM index (HGFM) to index a whole-genome and population of genomes.
RNA-seq; Sequencing; Mapping
Kim D, Langmead B, Salzberg SL "HISAT: a fast spliced aligner with low memory requirements." Nat Methods. 2015 Apr;12(4):357-60. https://doi.org/10.1038/nmeth.3317
PMID: 25751142
PMCID: PMC4655817
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