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SC3

SC3

SC3 is a tool to cluster consensus sequences of single-cell RNA-seq (scRNA-sq) data. The SC3 algorithm uses unsupervised learning method.

Topic

RNA-Seq

Details

  • Operation: Sequence clustering; RNA-Seq analysis
  • Software interface: Command-line user interface; Library
  • Language: R
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: GPL-3.0
  • Cost: Free
  • Version name: 1.14.0
  • Maturity: Stable
  • Credit: Wellcome Trust, FRS-FNRS; the Belgian Network DYSCO (Dynamical Systems, Control, and Optimisation) funded by the Interuniversity Attraction Poles Programme initiated by the Belgian State Science Policy Office; and the ARC (Action de Recherche Concerte) on Mining and Optimization of Big Data Models funded by the Wallonia-Brussels Federation, EPSRC the Sanger Institute and a Chancellors fellowship from the University of Edinburgh, Bloodwise, the Medical Research Council, the Kay Kendall Leukaemia Fund, the Cambridge NIHR Biomedical Research Center, the Cambridge Experimental Cancer Medicine Centre, the Leukemia and Lymphoma Society of America, the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute.
  • Contact: Vladimir Kiselev vladimir.yu.kiselev _at_ gmail.com
  • Collection: Bioconductor

Publications

Kiselev VY, Kirschner K, Schaub MT, Andrews T, Yiu A, Chandra T, Natarajan KN, Reik W, Barahona M, Green AR, Hemberg M "SC3: consensus clustering of single-cell RNA-seq data." Nat. Methods 2017; 14(5):483-486 https://doi.org/10.1038/nmeth.4236
PMID: 28346451
PMCID: PMC5410170


Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J1, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M "Orchestrating high-throughput genomic analysis with Bioconductor." Nat Methods. 2015 Feb;12(2):115-21. https://doi.org/10.1038/nmeth.3252
PMID: 25633503
PMCID: PMC4509590


Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. "Bioconductor: open software development for computational biology and bioinformatics." Genome Biol. 2004;5(10):R80. Epub 2004 Sep 15. https://doi.org/10.1186/gb-2004-5-10-r80
PMID: 15461798
PMCID: PMC545600


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