SCOUT is a tool to infer pseudo-time ordering and bifurcation trajectories in single-cell RNA-seq (scRNA-seq) data. The SCOUT algorithm uses the fixed-radius near neighbors algorithms for cell densities to identify cell states, and use the minimum spanning tree to compute branching. SCOUT determines a weighted distance to using a projection of Apollonian circle to compute the pseudo-time trajectories cells.
Gene expression; RNA-seq
Wei J, Zhou T, Zhang X, Tian T "SCOUT: A new algorithm for the inference of pseudo-time trajectory using single-cell data." Comput Biol Chem. 2019 Jun;80:111-120. https://doi.org/10.1016/j.compbiolchem.2019.03.013
PMID: 30947069
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