SCmut is a tool for the detection of cells that contain mutations in RNA-seq and bulk-cell DNA-sequencing data. The SCmut algorithm can use a list of somatic mutations in the absence of DNA-sequencing data.
Genomics; Oncology; RNA-seq
Vu TN, Nguyen HN, Calza S, Kalari KR, Wang L, Pawitan Y "Cell-level somatic mutation detection from single-cell RNA-sequencing." Bioinformatics. 2019 Apr 26. pii: 5480302. https://doi.org/10.1093/bioinformatics/btz288
PMID: 31028395
Chung W, Eum HH, Lee HO, Lee KM, Lee HB, Kim KT, Ryu HS, Kim S, Lee JE, Park YH, Kan Z, Han W, Park WY "Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer." Nat Commun. 2017 May 5;8:15081. https://doi.org/10.1038/ncomms15081
PMID: 28474673
PMCID: PMC5424158
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