A tool for rare variant genotype imputation. The GIGI algorithm can handle large pedigrees. Only a subset of individuals in a pedigree needs to be completely sequenced, GIGI will infer the missing genotypes at untyped markers, if the remaining individuals are sequenced solely at appropriate marker locations. GIGI-Quick can speed up the computation by running GIGI in parallel. See 'links'.
Population genetics
Cheung CY, Thompson EA, Wijsman EM "GIGI: an approach to effective imputation of dense genotypes on large pedigrees." Am J Hum Genet. 2013 Apr 4;92(4):504-16. https://doi.org/10.1016/j.ajhg.2013.02.011
PMID: 23561844
PMCID: PMC3617386
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