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Minimac2 is a tool for genotype imputation. The Minimac2 Algorithm is a computationally efficient implementation of MaCH algorithm, works on phased genotypes and can handle large reference panels up to hundreds of thousands of haplotypes. A multiprocessor version, minimac2-omp is available from the download page.


Population genetics


  • Operation: Imputation
  • Software interface: Command-line user interface
  • Language: C++;C
  • Operating system: Linux
  • License: Other
  • Cost: Free
  • Version name: 2014.9.15
  • Maturity: Stable
  • Credit: National Institutes of Health (NIH)
  • Contact: Goncalo Abecasis goncalo _at_ | Christian Fuchsberger cfuchsb _at_
  • Collection: Minimac


Fuchsberger C, Abecasis GR, Hinds DA "minimac2: faster genotype imputation." Bioinformatics. 2015 Mar 1;31(5):782-4. 2014 Oct 22.
PMID: 25338720
PMCID: PMC4341061

Das S, Forer L, Schonherr S, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C "Next-generation genotype imputation service and methods." Nat Genet. 2016 Oct;48(10):1284-1287.
PMID: 27571263
PMCID: PMC5157836

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