A program to create multiple sequence alignments of a large number of sequences. Prominent features are rapid sequence distance computation using k-mer counting, a profile function computing a log-expectation scores, and tree-dependent partitioning of the sequences.
Genomics; Sequencing; Sequence analysis
Edgar RC "MUSCLE: a multiple sequence alignment method with reduced time and space complexity." BMC Bioinformatics. 2004 Aug 19;5:113. https://doi.org/10.1186/1471-2105-5-113
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